This is a bit more complex question as it needs to take into account things like product and packaging materials and design, cost of the sterilization equipment and upkeep of that equipment, product transportation, sterilization indicator system, validation and requalification costs, routine sterilization costs, turnaround time, etc.
Once these questions are properly and thoughtfully answered, the decision as to the sterilization methodology, and whether to do this processing at a contract sterilization organization or in-house, should become self-evident.
